Research Article

Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine

Table 3

Module name and number as described in [12]. The “pediatric SLE” column is reproduced from GSE11909. The numbers shown are the percentage of genes from the module that have significant differential gene expression (DGE). Thus, the first row is interpreted as follows: 45% of the genes in Module 1.1 have significant DGE and are increased in expression. The second column, “Adult SLE, High versus No Activity,” is a DGE analysis between lupus patients with high disease activity and lupus patients with no activity. The third column, “Adult SLE versus HC” is a DGE analysis between a cohort of lupus patients with average disease activity and healthy controls.

Module nameModule number⁢Pediatric SLE
⁢Untreated versus HC
⁢Adult SLE
⁢High versus no activity
⁢Adult SLE
⁢SLE versus HC
UpDownUpDownUpDown

Plasma cells1.145080414
Erythrocytes1.25559207
B-cells1.314336130
None1.454518819
Myeloid1.5136915324
None1.655111045
Ribosomal1.70785641140
None1.835227621
Cytotoxic2.1221140229
Neutrophils2.2330550294
Erythrocytes2.32639398
Ribosomal2.4077074536
None2.51273365
Myeloid2.6232103288
None2.71310417
T-cells2.8042056132
None2.931281340
None2.148811188
None2.112628422
Interferon3.1910970970
Inflammation3.21321642014
Inflammation3.39687178
None3.4614216225
None3.5141855145
None3.665215219
None3.749123179
None3.8113145442
None3.9211129323