Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types

Figure 1

Methodology workflow. (a) The NCBI RefSeq dataset was submitted to TMHMM and selected for the presence of a transmembrane domain. Proteins containing only a signal peptide (classified as secreted) or belonging exclusively to other membranes were excluded, giving a final set of 3.758 genes coding for cell surface proteins. (b) TCGA data as used to calculate the -score for the surfaceome set allowing the identification of putative surfaceome cancer genes.

(a)

(b)