Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains

Table 1

List of human herpesviruses and their related diseases as discussed in a review by Gilden et al. [6].

Virus species	Disease	Viral strain used in this study; NCBI accession number	Proteins,; nucleotide length (bp),; GC (%),
⁢ Alphaherpesvirinae  subfamily
HHV-1/human herpesvirus 1/herpes simplex virus 1/HSV-1	Encephalitis	Human herpesvirus 1 NC_001806	77, 152,222, 68.3
HHV-2/human herpesvirus 2/herpes simplex virus 2/HSV-2	Genital herpes, aseptic meningitis, and recurrent radiculopathy	Herpes simplex virus type 2 (strain HG52) NC_001798	77, 154,675, 70.4
HHV-3/human herpesvirus 3/Varicella zoster virus/human herpesvirus 3/VZV	Chickenpox (Varicella)	Human herpesvirus 3 (strain Dumas) NC_001348	73, 124,884, 46
⁢Betaherpesvirinae  subfamily
HHV-5/human herpesvirus/Cytomegalovirus	Congenital infection, microcephaly, seizures, hypotonia, spasticity, Guillain-Barre syndrome, and acute brachial plexopathy	Human herpesvirus 5 strain Merlin NC_006273	169, 235,646, 57.5
HHV-6/human herpesvirus 6/T-cell lymphotropic virus	Roseola, febrile seizures, and fulminant hepatitis	Human herpesvirus 6A NC_001664	88, 159,322, 42.4
		Human herpesvirus 6B strain Z29 NC_000898	104, 162,114, 42.8
HHV-7/human herpesvirus 7	Encephalitis	Human herpesvirus 7 strain RK NC_001716	86, 153,080, 36.2
⁢Gammaherpesvirinae subfamily
HHV-4/human herpesvirus 4/Epstein-Barr virus	Aseptic meningitis, encephalomyeloneuritis, and neuritis	Human herpesvirus 4 NC_007605	95, 171,823, 59.5
		Human herpesvirus 4 strain AG876 NC_009334	80, 172,764, 59.5
HHV-8/human herpesvirus 8/Kaposi’s Sarcoma-associated herpesvirus	Kaposi’s sarcomas	Human herpesvirus 8 strain GK18 NC_009333	86, 137,969, 53.8