An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations

Table 1

Drugs and their predicted differentially expressed targets in Mir2Drug database.

Drug	SNP ID	Gene symbol	miRNA	Wild free energy	Mutation free energy	(kcal/mol)	Effect class	Literature
TLE	rs764927448	BTG1	hsa-miR-1255b-5p	−0.26	0.8	−1.06	Partial loss	[23]
Recombinant bromelain	rs764927448	BTG1	hsa-miR-1255b-5p	−0.26	0.8	−1.06	Partial loss	[24]
IGF-I	rs764927448	BTG1	hsa-miR-1255b-5p	−0.26	0.8	−1.06	Partial loss	[25]
Anti-HER2/neu trastuzumab antibody	rs746218880	WT1	hsa-miR-1193	None	−8.11	8.11	Complete gain	[26]
Norlichexanthone and anomalin A	rs72552389	PIM1	hsa-miR-7114-5p	None	−11.12	11.12	Complete gain	[27]