Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis
Gene expression profiles of three genes regulated in both animal model and human blood samples. (a) Clustering of the OA patients based on the expression of three genes commonly regulated in the blood of rats and humans. mRNA abundance levels measured by the microarrays were obtained from the GARP study . The dataset consists of blood gene expression profiles of 106 OA patients and 33 controls (OA samples were indicated by green while controls by violet colors). The intensity of the color is proportional to the standardized values (between −3 and 3) from each microarray, as indicated on the bar below the heat map image. Hierarchical clustering was performed with the dChip software using correlation distance metric and centroid linkage method. (b) Time course of gene expression alterations in rat blood of the selected genes. The profiles of individual animals are presented ().
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