Characteristics and Validation Techniques for PCA-Based Gene-Expression Signatures

Figure 4

Validation plot for TvsN-100 signature applied to Breast dataset. To demonstrate a signature that is valid within the Breast dataset, the TvsN-100 gene signature was applied. The probesets for the TvsN-100 signature are coherent (a), and the PCA model is robust (b). The signature is also unique (c) and describes the same biology as in the dataset that it was trained upon (d).

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