Characteristics and Validation Techniques for PCA-Based Gene-Expression Signatures

Figure 6

Correlation between the PCA scores from different mixed-gene signatures and the Gender-29 and TvsN-100 signature applied to the DC dataset. Even when five TvsN probesets are removed, the Mix-29/24 model is still correlated with the TvsN-100 signature (a). This correlation further decreases when more probesets are removed (b), until it is finally gone (c). The Mix-29/14 signature is, instead, correlated with the Gender-29 signature (d). The Gender-29 signature is less correlated with the Mix-29/19 signature (e) and shows no correlation with the Mix-29/24 signature (f).

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