MicroRNA Profiling in Cartilage Ageing

Figure 3

The position of the DE miRNAs in the chondrocyte expression network. Gene ontology biological processes associated with dysregulated miRNA targets were identified following TargetScan filter module in IPA. ToppGene was used to perform functional enrichment analysis on predicted miRNA targets to highlight biological processes most significantly affected by dysregulated miRNA-mRNA interactions. GO terms (FDR < 0.05) were summarized and visualised using REViGO and Cytoscape. Allowed similarity setting in Revigo was medium. The main clusters of biological processes significantly influenced by dysregulated miRs in (a) all young compared to all old samples and (b) all young samples compared to selection 4. The line width specifies the amount of similarity.

(a)

(b)