Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML

Figure 3

Methylation distribution in genomes. (a) Methylation distribution (beta value) across all promoters that follow bimodal distribution pattern. (b) Methylation value density estimation in all samples at different CpG region. (c) IDH1 R172-positive and IDH1 R172-negative patient’s promoter methylation distribution. Negative patient distribution is similar with (a), but positive patients show lower density. (d) T (9; 11)-positive and T (9; 11)-negative patient’s promoter methylation distribution, and here, also positive patients show lower density.

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