Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences

Table 2

Diversity values at amino acid positions in Vpr. Each position in the table had at least one diversity value greater than 2 in the full amino acid alphabet. A diversity value greater than 2 (bold) indicates a diverse amino acid position.

Position	Coreceptor	All residues	Murphy-15	Murphy-10	Murphy-8	Murphy-4
28	X4	4.45	4.45	3.18	3.18	1.99
	R5	3.37	3.37	2.95	2.95	1.76
37	X4	5.46	2.27	2.27	2.27	1.94
	R5	4.97	3.14	2.93	2.92	2.16
41	X4	2.88	2.88	2.65	2.65	1.45
	R5	2.63	2.63	2.55	2.55	1.64
45	X4	2.20	2.20	2.20	2.20	2.20
	R5	2.14	2.14	2.14	2.14	2.08
55	X4	1.87	1.87	1.87	1.87	1.00
	R5	2.78	2.76	2.74	2.74	1.38
77	X4	2.07	2.07	2.07	2.07	1.00
	R5	2.31	2.31	2.31	2.31	1.02
84	X4	2.94	2.20	2.20	2.20	2.20
	R5	2.97	2.55	2.38	2.38	2.15
85	X4	2.71	2.71	2.71	2.71	1.78
	R5	2.68	2.66	2.66	2.66	1.68
89	X4	1.97	1.97	1.83	1.83	1.00
	R5	3.42	3.24	3.06	3.02	1.50
93	X4	2.23	2.23	1.83	1.83	1.00
	R5	1.94	1.94	1.82	1.82	1.00