Research Article
Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis
Table 2
Single site test of genetic variants in T1D and controls.
| | Regions | SNP | Patients (%) | Controls (%) | χ2 | values |
| | Exon 2 | rs2228570 (FokI) | | | | | | Genotype | | | | | | CC | 84 (82.4%) | 0 (0.0%) | 182.95 | 0.0016 | | CT | 13 (12.7%) | 0 (0.0%) | | TT | 5 (4.9%) | 100 (100%) | | Allele | | | | | | C | 181 (88.7%) | 0 (0%) | 321.48 | 0.0015 | | T | 23 (11.3%) | 200 (100%) |
| | Intron 8 | rs7975232 (ApaI) | | | | | | Genotype | | | | | | GG | 33 (32.4%) | 86 (86.0%) | 64.34 | 0.014 | | GT | 26 (25.5%) | 0 (0.0%) | | TT | 43 (42.2%) | 14 (14.0%) | | Allele | | | | | | G | 92 (45.1%) | 172 (86%) | 74.61 | 0.015 | | T | 112 (54.9%) | 28 (14%) |
| | Exon 9 | rs731236 (TaqI) | | | | | | Genotype | | | | | | CC | 204 (100%) | 200 (100%) | 1.01 | 0.310 | | Allele | | | | | | C | 204 (100%) | 200 (100%) | 1.01 | 0.496 |
| | Intron 8 | KT280406 | | | | | | Genotype | | | | | | CG | 20 (4.1%) | 0 (0%) | 21.76 | 0.006 | | GG | 184 (95.9%) | 30 (100%) | | Allele | | | | | | C | 20 (9.8%) | 0 (0%) | 20.63 | 0.026 | | G | 184 (90.2)% | 200 (100%) |
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χ2: chi-square test; represents significance at the 0.05 level.
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