HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways

Figure 5

The molecular mechanism of HDJX in attenuating diabetic retinopathy in rats via the inhibition of SOCS3-STAT3 and T1MP1-A2M pathways. JAK2, NF-κB, and p38 MAPK promote SOCS3-STAT3 signalling, then SOCS3-STAT3 is involved in the progression of DR. TIMP1 and A2M play roles in matrix degradation which also take part in the process of DR. HXJD has the ability of inhibiting these pathological changes and thereafter it will ameliorate DR.