Research Article
HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways
Table 2
Top 10 canonical pathways identified using IPA (upregulated by HXJD).
| | Ingenuity canonical pathways | value | Affected molecules |
| | Phototransduction pathway | 2.57E−04 | ARR3, GRK1, and PDE6D | | The visual cycle | 5.50E−04 | RDH11, RDH12 | | RAR activation | 1.00E−03 | RDH11, ADCY1, RDH12, and CITED2 | | Retinoate biosynthesis I | 2.69E−03 | RDH11, RDH12 | | Retinol biosynthesis | 2.69E−03 | RDH11, RDH12 | | Creatine-phosphate biosynthesis | 1.17E−02 | CKMT1A/CKMT1B | | Protein kinase A signalling | 1.26E−02 | H3F3A/H3F3B, ADCY1, GRK1, and PDE6D | | NAD biosynthesis III | 1.26E−02 | Nmnat3 | | NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde | 1.62E−02 | Nmnat3 | | NAD salvage pathway III | 1.62E−02 | Nmnat3 |
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