Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

Table 2

Serum concentrations of ACTH, TSH, CORT, CA, testosterone, and serotonin.

Group	ACTH (pg/ml)	TSH (μIU/ml)	CORT (μg/ml)	CA (pg/ml)	Testosterone (pg/ml)	Serotonin (ng/ml)
N	154.28 ± 24.71	0.19 ± 0.03	22.18 ± 4.35	258.03 ± 39.97	420.53 ± 76.05	508.03 ± 69.72
NGS	156.44 ± 30.53^##	0.18 ± 0.03^##	25.27 ± 3.78^##	258.94 ± 38.43^##	427.69 ± 86.54^#	515.19 ± 91.49^#
WP	168.94 ± 34.98^##	0.20 ± 0.03^#	26.27 ± 6.42^#	272.69 ± 41.88^##	387.69 ± 46.36^#	522.69 ± 62.73^#
M	238.56 ± 50.39	0.27 ± 0.07	40.61 ± 13.87	327.69 ± 25.48	331.06 ± 46.34	606.06 ± 64.59
MGS	187.66 ± 41.68^#	0.21 ± 0.04^#	28.77 ± 6.06^, #	296.44 ± 26.62^, #	375.19 ± 35.03^#	546.44 ± 42.47^#

Significant differences were determined by one-way ANOVA. and versus the N group; ^## and ^# versus the M group. Data are mean ± SD, . NGS: normal animal administrated with total ginsenoside (GS) group; WP: wide platform group; M: SD model group; MGS: model administrated with GS group; ACTH: adrenocorticotropic hormone; TSH: thyroid-stimulating hormone; CORT: corticosterone; CA: catecholamine. Normal, WP, and model received normal saline solution; NGS and MGS received GS orally at a daily dose of 100 mg/kg of body weight from day 1 to day 8.