Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas
Table 2
Correlation of the clinicopathological parameters with Dicer, Drosha, AGO2, and DGCR8 mRNA expression levels in Asian Korean PTC specimens.
Dicer
P
Drosha
P
DGCR8
P
AGO2
P
Low
High
Low
High
Low
High
Low
High
Age
0.779
0.310
0.297
0.745
<40
9
5
7
7
12
2
8
6
41–50
10
1
8
2
7
3
7
3
>50
9
6
9
7
11
5
11
5
T stage
0.120
0.161
0.170
0.455
(1)
16
5
14
7
14
7
12
9
(2)
12
5
10
7
14
3
13
4
(3)
0
2
0
2
2
0
1
1
N stage
0.369
0.121
0.855
0.816
(+)
12
7
9
10
14
5
12
7
(−)
16
5
15
6
16
5
14
7
M stage
1.000
0.400
1.000
1.000
(+)
1
0
0
1
1
0
1
0
(−)
28
12
24
15
29
10
25
14
Histologic stage
0.562
0.215
0.609
(i)
13
3
11
5
13
3
10
6
(ii)
3
2
4
1
3
2
4
1
(iii)
4
5
4
5
7
2
5
4
(iv)
8
2
5
5
7
3
7
3
Extrathyroidal extension
0.716
0.503
0.124
0.750
(+)
18
9
15
12
18
9
18
9
(−)
10
3
9
4
12
1
8
5
Bilateral lobe involvement
0.677
0.690
0.388
0.416
(+)
5
3
4
4
5
3
4
4
(−)
23
9
20
12
25
7
22
10
Multifocality
1.000
0.094
1.000
0.608
(+)
11
4
6
9
11
4
9
6
(−)
17
8
18
7
19
6
17
8
Linear by linear association. Fisher’s exact test. Pearson’s Chi-squared test.
