(a)
(b)
Figure 3: Hierarchical clustering of the pPTBsigs in Test_set (a) and Longitudinal_set (b). pHC = pPTBsigs based on the four cell populations from HC donors in Test_set with no exchange of cell proportions. pHC_Mono::Neut = pPTBsigs based on the four cell populations from HC donors in Test_set with the exchange of cell proportions between neutrophils and monocytes. The other pPTBsig names were derived by the similar abbreviation. PTB_0 m = PTBsigs in whole blood of PTB patients at initiation of drug treatment. PTB_2 m = PTBsigs in whole blood of PTB patients 2 months after drug initiation. PTB_12 m = PTBsigs in whole blood of PTB patients 12 months after drug initiation.