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International Journal of Genomics
Volume 2017 (2017), Article ID 5831020, 13 pages
https://doi.org/10.1155/2017/5831020
Research Article

A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density

1Consorcio de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico
2Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica, Mexico City, Mexico
3Statistical Genetics, Biogen, Cambridge, MA, USA
4Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, JAL, Mexico
5División de Genética, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, JAL, Mexico
6Instituto Nacional de Medicina Genómica, Mexico City, Mexico
7Unidad de Vigilancia Epidemiológica Hospitalaria, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
8Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, MOR, Mexico
9Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, MOR, Mexico

Correspondence should be addressed to Rafael Velázquez-Cruz; xm.bog.negemni@zeuqzalevr

Received 28 December 2016; Revised 24 May 2017; Accepted 21 June 2017; Published 3 August 2017

Academic Editor: Graziano Pesole

Copyright © 2017 Marisela Villalobos-Comparán et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1 Demographic characteristics and BMD of the discovery and replication samples. Table S2 Top SNPs associated with FN-BMD in the discovery sample (P < 5 x 10-5). Table S3 Top SNPs associated with LS-BMD in the discovery sample (P < 5 x 10-5). Table S4 Proxy SNPs for the GEFOS included in the discovery sample. Figure S1 Principal component analysis calculated for all the Postmenopausal women included in the study. The colors in the legend denote the ethnic group: EUR, AFR, NAT, MOR and GUAD. Postmenopausal women of Discovery sample (MOR), PC1 and PC2 were calculated using 60, 793 AIMs. Postmenopausal women of replication sample (GUAD), PC1 and PC2 were calculated using 96 AIMs with MAF > 5% and missing call rate < 5%. Figure S2 Manhattan plots of the genome-wide association results of the discovery sample. Figure S3 Linkage Disequilibrium (LD) plots with the D’ values for the SLIT3 and CCDC170 genes. Figure S4 Linkage Disequilibrium (LD) plots with the D’ values for the HDAC9 and SHFM1 genes.

  1. Supplementary material