A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density

Table 1

Associated SNPs with femoral neck and lumbar spine BMD in discovery and replication samples.

SNP	Physical position	CHR	Gene	A1/A2^a	Discovery BMD^b			Replication BMD^c			Meta-analysis	P-Het^d	GEFOS look-up^e
					MAF	β	P	MAF	β	P	P		MAF	β	P
rs1432910	168,391,557	5	SLIT3	T/C	0.48	−0.031	4.84 × 10^−5	0.48	−0.015	0.231	—	0.264	0.49	−0.012	0.598
rs2278391	168,445,608	5	SLIT3	A/G	0.27	0.038	4.31 × 10^−6	0.28	0.003	0.798	—	0.795	0.21	0.001	0.747
rs6904364	151,754,273	6	RMND1	C/T	0.38	0.028	3.63 × 10^−4	0.38	0.027	0.032	2.77 × 10^−4	0.993	0.32	—	0.008
rs17081341	151,837,570	6	CCDC170	G/A	0.17	0.041	3.86 × 10^−5	0.13	0.041	0.015	1.62 × 10^−5	0.999	0.04	0.0001	0.054
rs849172	43,765,667	7	COA1	T/C	0.44	0.033	1.79 × 10^−5	0.49	−0.012	0.362	—	0.180	0.46	0.008	0.049
rs11764843	18,935,310	7	HDAC9	A/C	0.49	−0.045	7.12 × 10^−6	0.48	−0.010	0.541	—	0.584	0.42	−0.008	0.521
rs17413103	96,369,421	7	SHFM1	A/C	0.11	0.076	8.76 × 10^−6	0.09	−0.003	0.918	—	0.471	0.08	0.019	0.105

MAF: minor allele frequency; CHR: chromosome; value for additive model, adjusted for age, body mass index, and principal components. — means information not available for this SNP. ^aA1 represents the minor allele. ^bMexican-Mestizo women from Central México (Morelos state), . ^cMexican-Mestizo women from Western Mexico (Guadalajara City), . ^dP-Het, P-heterogeneity for meta-analysis. ^eGEFOS dataset release 2012; beta values obtained from GEFOS data release 2015.