A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density

Table 2

Allele frequency of SNPs associated with BMD phenotypes in the discovery sample and comparison with other populations.

			Minor allele frequency
SNP	CHR	Gene	CEU^a	MXL^a	MX^b	AMR^c
rs1432910	5	SLIT3	0.56	0.44	0.48	0.58
rs2278391	5	SLIT3	0.16	0.24	0.27	0.39
rs6904364	6	RMND1	0.37	0.41	0.38	0.36
rs17081341	6	CCDC170	0.03	0.16	0.17	0.24
rs11764843	7	HDAC9	0.65	0.48	0.49	—
rs17413103	7	SHFM1	0.09	0.09	0.11	0.11

— means information not available for this SNP; CEU: Utah residents with Northern and Western European ancestry; MXL: Mexican Ancestry in Los Angeles, California. ^aData obtained from 1000 Genomes dataset. ^bMX: Mexican-Mestizo population from Central México (Morelos state). ^cAMR: Amerindian population of Nahua, Totonac, and Zapotec. Data were obtained from Consortium for the Study of Genomic Diversity of the Indigenous Populations.