A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density

Table 3

Comparison of SNP effect sizes for BMD between GEFOS genome-wide meta-analysis and this study.

GEFOS genome-wide meta-analysis^a					This study
SNP	Locus	Gene	Beta	value	Proxy SNP	Beta	value
Femoral neck BMD
rs1026364	3q13.2	KIAA2018	0.03	8.86 × 10^−7	rs9813630	0.018	0.046
rs4869742	6q25.1	CCDC170	−0.05	3.14 × 10^−13	rs4870044	−0.025	0.0007
rs3801387	7q31.31	WNT16	−0.08	2.78 × 10^−33	rs3779381	−0.025	0.007
rs13245690	7q31.31	CPED1	0.02	8.20 × 10^−4	rs13245690	0.021	0.026
rs7108738	11p15.2	SOX6	−0.08	3.52 × 10^−26	rs7128738	−0.029	0.001
rs227584	17q21.31	C17orf53	−0.06	3.15 × 10^−18	rs227584	−0.016	0.037
Lumbar spine BMD
rs7584262	2p21	PKDCC	0.01	0.05	rs11887431	0.057	0.0006
rs344081	3q25.31	LEKR1	0.05	1.49 × 10^−8	rs344081	0.043	0.032
rs3801387	7q31.31	WNT16	−0.11	6.38 × 10^−51	rs3779381	−0.036	0.005
rs13245690	7q31.31	CPED1	0.05	1.65 × 10^−11	rs13245690	0.031	0.020
rs7108738	11p15.2	SOX6	−0.03	5.76 × 10^−5	rs7128738	−0.030	0.021

^aData of effect sizes for the SNP and BMD site (stage 1 + stage 2) were obtained from Supplemental Table S, Estrada et al. [16]. Bold indicates values > 0.001 ().