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International Journal of Genomics
Volume 2017, Article ID 6923849, 14 pages
Research Article

Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans

1Department of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Debrecen, P.O. Box 63 H-4010, Hungary
2Department of Zoology, Faculty of Sciences, Eszterházy Károly University, Eger, Eszterházy tér 1 H-3300, Hungary
3Department of General and Environmental Microbiology, Faculty of Sciences, University of Pécs, Pécs, P. O. Box 266 H-7601, Hungary
4Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-701, Republic of Korea
5Department of Bacteriology, University of Wisconsin, 1550 Linden Dr., Madison, WI 53706, USA

Correspondence should be addressed to Tamás Emri; uh.bedinu.ecneics@samat.irme

Received 19 December 2016; Revised 17 May 2017; Accepted 13 June 2017; Published 9 July 2017

Academic Editor: Marco Gerdol

Copyright © 2017 Erzsébet Orosz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1 - List of primer pairs used in this study. Supplementary Table 2 - Number and stress responsiveness of genes showing altered regulation by deleting atfA. Supplementary Table 3 - Gene enrichment analysis of stress responsive genes. Sheet 1 - Control strain (up- and down-regulated gene groups). Sheet 2 - ΔatfA mutant strain (up- and down-regulated gene groups). Sheet 3 - AtfA-dependent genes (up- and down-regulated gene groups). AspGD Gene Ontology Term Finder ( applying default settings and biological process ontology GO terms as well as the FungFun2 package (, with default settings and FunCat categories were used. Only hits with p-value < 0.05 were taken into consideration during the evaluation process. Supplementary Table 4 - Selected significant shared GO, FunCat and KEGG pathway terms and their stress dependence under MSB, tBOOH or diamide induced stresses. Supplementary Table 5 - Microarray data of genes belonging to selected gene groups. Composition of the gene groups are defined in the Materials and methods section. Microarray data are expressed as log2 R values. R is equal to SItreated/SIuntreated and SI values stand for the normalized microarray signal intensities.

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