An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Table 1

Significant gene-gene interactions in both the discovery stage and the confirmatory stage.

CHR1

SNP1

MA1

CHR2

SNP2

MA2

P_BOOST

P_SBP

B_SBP

P_DBP

B_DBP

P_HTN

LOR_OR_HTN

GENE1

GENE2

4

rs4235144

C

6

rs9489622

G

6.55E-10

0.0063

24.35

0.0155

16.43

GABRB1

MAN1A1

4

rs4235144

T

6

rs9481890

T

6.41E-10

0.0067

24.20

0.0153

16.12

GABRB1

MAN1A1

12

rs2058798

A

15

rs3913226

T

9.38E-10

0.0391

−16.72

LMO3

NPAP1/SNRPN

15

rs1909884

A

16

rs17284390

G

3.38E-10

0.0479

2.54

CHRNA7

CDH13

18

rs17688362

T

22

rs12484954

C

5.21E-10

0.0436

−2.03

0.0057

−0.56

RNA5SP455/KRT8P5

DNAL4

Note. CHR represents chromosome. SNP is single-nucleotide polymorphism. MA means minor allele. P_BOOST is the value of the BOOST test in the offspring sample. P_SBP is the value of the linear regression on systolic blood pressure in the original sample. P_DBP is the value of the linear regression on diastolic blood pressure in the original sample. P_DBP is the value of the logistic regression on hypertension in the original sample. ∗ indicates the SNP is located outside of the gene region.