| | Authors and year | Exposure | Study design | Enrolled population | Samples | Techniques | ↑ miRNAs | ↓ miRNAs |
| | Li et al., 2015 [56] | Organic and inorganic environmental pollutants | Prospective | 110 clinical normal pregnant women | Placental tissue | NanoString | miR-651 (Pb exposure)
miR-1537 (Cd exposure)
miR-188-5p (PBDE high brominated congener 209 exposure)
miR-1537 (PCB congener 52 and 10 and total PCB exposure) | miR-151p, miR-10a, miR-193b, miR-1975, miR-423-5p, miR-520d-3p, miR-96, miR-252a, miR-518d-5p, miR-520a-5p, miR-190, let-7a, let-7b, let-7c, let-7d, let-7g, and let-7i (Hg exposure)
let-7f, miR-146a, miR-10a, and miR-431 (Pb exposure)
let-7c (PBDE low brominated congener 99 exposure) | | Tsamou et al., 2016 [57] | PM2.5, NO₂ | Prospective | 210 mother-newborn pairs | Placental tissue | qRT-PCR | 1st trimester
miR-20a, miR-21 (PM2.5 exposure)
miR-21 (NO₂ exposure) | 1st trimester
— | 2nd trimester
— | 2nd trimester
miR-16, miR-21, miR-146a, and miR-222 (PM2.5 exposure)
miR-20a, miR-21, and miR-146a (NO₂ exposure) | 3rd trimester
— | 3rd trimester
miR-146a, (PM2.5 exposure) | | LaRocca et al., 2016 [58] | Endocrine Disrupting Chemicals | Prospective | 179 women | Maternal urine + placental tissue | PCR Array + qRT-PCR | mir-15a-5p (Σ phenols, Σ parabens male placentas)
mir-185 (Σ DEHPm, Σ LMW) | mir-15a-5p (Σ phenols, Σ parabens female placentas and nonparabens, overall)
miR-142-3p (Σ phenols, Σ parabens, Σ nonparabens overall)
mir-185 (Σ phthalates, Σ HMW, overall) |
|
|
