Module Anchored Network Inference: A Sequential Module-Based Approach to Novel Gene Network Construction from Genomic Expression Data on Human Disease Mechanism

Figure 1

Schematic of MANI steps. Step 1: selection of three genes, , , and , for the initial window. Step 2: inferring regulatory relationship among genes within the window as indicated by arrows. External input is shown by . Step 3: migrating window to accommodate a new gene () with the closest expression association with two genes (genes and ) and their associated regulatory relationships from the previous window. Step 4: inferring regulatory relationships between the genes in the new window. Steps 3 and 4 are repeated until all the genes in the network are included in a window at least once.