Module Anchored Network Inference: A Sequential Module-Based Approach to Novel Gene Network Construction from Genomic Expression Data on Human Disease Mechanism

Figure 5

Window #2 optimal regulatory relationship. Expression profiles of all three genes showed nonzero lags (CEBPa (6 hours), CEBPg (6 hours), and PPARg (12 hours)). Between the two genes with shortest lags, CEBPa showed a better fit with external input . The input was a sigmoid function to produce a delayed response in the activity of gene CEBPa. Parallel and serial regulatory relationships were tested and the above optimal regulatory relationship yielded the smallest BIC score.