Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Figure 1

Hsa21 miRNAs. miR-99a-5p, let-7c-5p, and miR-125b-2-5p are located on Hsa21 in the sense orientation within an intron of the C21orf34 gene, located at the beginning of q21.1 band. miR-99a-5p and let-7c-5p are only 659 bp apart, whereas miR-125b-2-5p lies just over 50.000 bp downstream of let-7c. miR-155-5p is located within the BIC gene, almost 9 Mb downstream from the C21orf34 gene at Hsa21 genomic position q21.1. Finally, miR-802-5p is located just over 10 million bp downstream from the BIC/miR-155 gene in the antisense orientation within intron 1 of the RUNX1 gene at position q22.11.