Association of PTPN22 Haplotypes (−1123G>C/+1858C>T) with Rheumatoid Arthritis in Western Mexican Population

Table 3

Frequencies of −1123G>C and +1858C>T PTPN22 haplotypes in RA seropositive patients stratified according to anti-CCP antibodies status.

	GC% (n)	CT% (n)	OR	95% CI	p value
Anti-CCP low	3.9 (5)	0 (0)	—	—	—
Anti-CCP high	82.8 (106)	100 (3)	1.028	(0.996–1.061)	0.873

to antibodies values that are > than the upper limit of normal (ULN) and ≤ 3 times the ULN for laboratory assay; to antibodies values that are > than 3 times ULN for laboratory assay (according to ACR/EULAR 2010 criteria). OR: odds ratio; 95% CI: confidence interval; anti-CCP: anti-cyclic citrullinated peptide; Ab: antibody; RA: rheumatoid arthritis. The haplotypes include only homozygous individuals for each polymorphism.