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International Journal of Genomics
Volume 2017, Article ID 9481756, 12 pages
https://doi.org/10.1155/2017/9481756
Research Article

Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis

1Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
2Center for Nuclear Energy in Agriculture, University of Sao Paulo, 13400-970 Piracicaba, SP, Brazil
3Escola de Veterinária, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
4Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, MG, Brazil
5Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India

Correspondence should be addressed to Sintia Almeida; moc.liamg@adiemlaaitnis, Andrey P. Lage; moc.liamg@11egalpa, and Vasco Azevedo; moc.liamg@notsiraocsav

Received 7 July 2016; Revised 2 October 2016; Accepted 23 October 2016; Published 20 February 2017

Academic Editor: Wen-Chi Chou

Copyright © 2017 Sintia Almeida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Based on the ability of nitrate reductase synthesis, Corynebacterium pseudotuberculosis is classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources. Apart from these two biovars, some other strains are also able to carry out the reduction of nitrate. The enzymes that are involved in electron transport chain are also identified by in silico methods. Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and the C. pseudotuberculosis pathogenicity, virulence factors, and discovery of drug targets.