Identification of Novel Causal FBN1 Mutations in Pedigrees of Marfan Syndrome

Figure 1

The proband pedigrees with MFS. +/− represents the heterozygous type; −/− represents the wild type. “Male” and “female” are indicated by squares and circles, respectively, and the filling symbols represent individuals affected with Marfan syndrome. The arrow shows the proband.

(a) Pedigree 1

(b) Pedigree 2

(c) Pedigree 3