Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions

Table 1

Pathway enrichment analysis of clustered or nonclustered miRNAs with SNPs in seed regions by using miEAA.

Term	value
Clustered miRNAs with SNPs in seed regions
Alzheimer disease amyloid secretase pathway (P00003)	0.0010
Selenium (WP15)	0.0020
TCR signaling pathway (WP69)	0.0028
IL-3 signaling pathway (WP286)	0.0031
IL-1 signaling pathway (WP195)	0.0036
Endochondral ossification (WP474)	0.0047
IL-5 signaling pathway (WP127)	0.0056
Natural killer cell-mediated cytotoxicity (hsa04650)	0.0062
G protein signaling pathways (WP35)	0.0066
IL-6 signaling pathway (WP364)	0.0075
IL-2 signaling pathway (WP49)	0.0078
EPO receptor signaling (WP581)	0.0081
Ubiquitin proteasome pathway (P00060)	0.0098
Nonclustered miRNAs with SNPs in seed regions
TCR signaling pathway (WP69)	0.0074
Id signaling pathway (WP53)	0.0097