Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

Table 3

Association between FDFT1 gene polymorphism and clinicopathological characteristics of Non-small Cell lung cancer.

Clinical characteristics	Genotype (N = 19)			Allele (N = 38)
Clinical staging	CC	CT	TT	T	C
Stage IIIA, IIIB	3 (15.79)	0 (0.0)	1 (5.26)	2 (5.26)	6 (15.79)
Stage IV	12 (63.16)	3 (15.79)	0 (0.0)	3 (7.89)	27 (71.05)
Fisher’s exact test
Metastasis
Positive	8 (42.11)	0 (0.0)	0 (0.0)	0 (0.0)	16 (42.1)
Negative	7 (36.84)	3 (15.79)	1 (5.26)	5 (13.16)	17 (44.74)
Fisher’s exact test
Treatment
Response	8 (42.11)	2 (10.53)	1 (5.26)	4 (10.53)	18 (47.37)
Nonresponse	7 (36.84)	1 (5.26)	0 (0.0)	1 (2.63)	15 (39.47)
Fisher’s exact test
NSCLC types
Adenocarcinoma	11 (57.89)	3 (15.79)	1 (5.26)	5 (13.16)	25 (65.79)
Squamous cell carcinoma	4 (21.05)	0 (0.0)	0 (0.0)	0 (0.0)	8 (21.05)
Fisher’s exact test

There is a significant correlation between metastatic status and C allele distribution ().