The Effect of Canertinib on Sensitivity of Cytotoxic Drugs in Tamoxifen-Resistant Breast Cancer Cells In Vitro

Figure 7

Effect of EGFR inhibition with canertinib treatment on the sensitivity of MCF-7 and MCF-7(TamR) cells to a 48-hour treatment with (a) paclitaxel and (b) daunorubicin. Cells were subjected to a 48-hour cytotoxic treatment with the addition of (red) 0 μM, (blue) 0.1 μM, or (green) 1 μM canertinib before 4 days recovery in the same medium minus the cytotoxic. values calculated from a paired t-test comparing growth inhibition between cells untreated with canertinib, both of which were treated with a given concentration of daunorubicin or paclitaxel. indicates of 0 μM canertinib. Error bars indicate standard deviation.

(a)

(b)