The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia

Table 4

Top differentially methylated CpG islands based on metabolic syndrome in males and females.

Female						Male
Chromosomal location (Chr:region)	Number of CpGs in island	Gene name	Fold change^a	Raw value	FDR-corrected value	Chromosomal location (Chr:region)	Number of CpGs in island	Gene name	Fold change^a	Raw value	FDR-corrected value
3: 185000558–185000896	33	Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)	−0.196	0.000936	0.0423	19: 46915312–46915802	44	Coiled-coil domain containing 8 (CCDC8)	0.0930	0.0000186	0.0325
13: 20135400–20136041	53	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (TPTE2)	0.0267	0.00101	0.0423	17: 40558006–40558274	19	Polymerase I and transcript release factor (PTRF)	−0.129	0.000278	0.102

Shows the CpG islands for the sex-specific methylation discovery analysis with an FDR < 0.1. FDR < 0.05 was considered significant. Column 1 provides the genomic location of the CpG island (GRCh37/hg19), column 2 provides the number of CpG sites located within the island according to annotation data, and column 3 provides the gene name where the CpG island is found. The remaining columns provide the fold change with direction, unadjusted, and FDR-corrected values. ^aFold change calculated by log2 of the quotient in methylation in subjects with metabolic syndrome compared to subjects without metabolic syndrome. Positive fold change indicates an increase in methylation (hypermethylation) in the metabolic syndrome group. indicates statistical significance based on an FDR cutoff below 0.05