Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease

Table 1

Enriched metabolic pathway in the coexpression network.

Term	Count	Pop	value	Genes
hsa00230: purine metabolism	17	176	8.46E − 11	5427, 9533, 2618, 6240, 5557, 11164, 6241, 26289, 270, 158, 93034, 8833, 10606, 471, 108, 107, 2983
hsa01130: biosynthesis of antibiotics	14	212	6.52E − 07	6120, 5224, 5232, 5223, 230, 2618, 26289, 270, 158, 8789, 92483, 10606, 471, 2027
hsa00240: pyrimidine metabolism	10	104	2.40E − 06	93,034, 5427, 9533, 7372, 7371, 6240, 5557, 7298, 6241, 7083
hsa00010: glycolysis/gluconeogenesis	7	67	1.06E − 04	92483, 5224, 5232, 5223, 230, 2027, 8789
hsa00670: one carbon pool by folate	4	20	0.001425311	1719, 471, 2618, 7298
hsa01230: biosynthesis of amino acids	6	74	0.001495954	6120, 5224, 5232, 5223, 230, 2027
hsa01200: carbon metabolism	7	113	0.001764573	6120, 5224, 5232, 5223, 230, 2027, 8789
hsa04913: ovarian steroidogenesis	5	49	0.002269906	1583, 108, 107, 3284, 1588
hsa00330: arginine and proline metabolism	5	50	0.002446109	84735, 1158, 4842, 57571, 1160
hsa00140: steroid hormone biosynthesis	5	58	0.004206383	1583, 1589, 3284, 1588, 1584
hsa00410: beta-alanine metabolism	4	31	0.005135035	84735, 2572, 57571, 8639
hsa00514: other types of O-glycan biosyntheses	4	31	0.005135035	10690, 135152, 27087, 23127
hsa00061: fatty acid biosynthesis	3	13	0.00927769	23205, 81616, 23305
hsa00790: folate biosynthesis	3	14	0.010744279	5860, 1719, 8836
hsa04925: aldosterone synthesis and secretion	5	81	0.013544109	1583, 108, 107, 1589, 3284
hsa00983: drug metabolism—other enzymes	4	46	0.015345429	8833, 7372, 7371, 7083
hsa01212: fatty acid metabolism	4	48	0.017202919	23205, 79966, 81616, 23305
hsa04922: glucagon signaling pathway	5	99	0.026291005	92483, 5224, 5223, 5837, 108
hsa00534: glycosaminoglycan biosynthesis—heparan sulfate/heparin	3	24	0.030276378	222537, 9348, 266722
hsa03320: PPAR signaling pathway	4	67	0.040871389	23205, 79966, 81616, 23305
hsa00030: pentose phosphate pathway	3	29	0.042939357	6120, 230, 8789
hsa00760: nicotinate and nicotinamide metabolism	3	29	0.042939357	93034, 27231, 23057