Allelic Switching of DLX5, GRB10, and SVOPL during Colorectal Cancer Tumorigenesis

Figure 3

Allelic quantification of three samples displaying allelic switching of SVOPL. The allelic composition of SVOPL cDNA for both normal and colorectal cancer (CRC) cDNA was tested by KASPar analysis (a) (blue: C allele; green: A allele). Validation of allelic quantification using Sanger sequencing confirmed the C allele to be most abundant in the normal cDNA samples, while the A allele was most abundant in the CRC samples. The investigated cSNP, rs2305816, is indicated with arrows (b).