Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses

Table 1

Haflinger samples selected for whole genome sequencing based on phenotype, age, DDB2 c.1013 C>T genotype, and ECA12 haplotype analysis.

Sample	Status	DDB2 genotype	Age at ocular exam	Features for selection
HF-14-62	Affected limbal SCC	C/C	13	Haplotype with majority case minor alleles
HF-14-55	Affected limbal SCC	C/C	6	Haplotype with majority case major alleles
HF-13-25	Affected limbal SCC	T/T	9	Defined 3 breakpoint of haplotype
HF-15-07	Affected limbal and nictitating membrane SCC	T/T	12	Defined 5 breakpoint of haplotype
HF-13-17	Unaffected	C/C	27	Oldest sample at the time of submission
HF-13-33	Unaffected	T/T	20	Risk haplotype