Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease

<div>TSHR and CTLA-4 linkage disequilibrium analysis diagram (<span class="nowrap"><svg height="13.5868pt" id="M126" style="vertical-align:-2.1507pt" version="1.1" viewbox="-0.0498162 -11.4361 27.6134 13.5868" width="27.6134pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M162 -163V703H101V-163H162Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.051,0)"><path d="M43 650V622C120 616 128 612 128 526V124C128 39 120 33 34 27V0H270C392 0 492 25 567 83C643 141 690 230 690 350C690 444 655 517 605 565C543 625 450 650 323 650H43ZM213 547C213 587 217 598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 529 592 439 592 336C592 176 505 36 319 36C246 36 213 55 213 131V547Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,16.642,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g><g transform="matrix(.013,0,0,-0.013,24.069,0)"><path d="M162 -163V703H101V-163H162Z"></path></g></svg>).</span> TSHR SNP sites rs179247, rs2284722, rs12101261, and rs4903964; TSHR SNP sites rs2300525 and rs17111394; and CTLA-4 sites rs231804, rs1024161, and rs231726 were located in the same haplotype region respectively; <svg height="13.5868pt" id="M127" style="vertical-align:-2.1507pt" version="1.1" viewbox="-0.0498162 -11.4361 27.6134 13.5868" width="27.6134pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M162 -163V703H101V-163H162Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.051,0)"><path d="M43 650V622C120 616 128 612 128 526V124C128 39 120 33 34 27V0H270C392 0 492 25 567 83C643 141 690 230 690 350C690 444 655 517 605 565C543 625 450 650 323 650H43ZM213 547C213 587 217 598 226 604C236 612 262 617 304 617C371 617 429 604 474 576C554 529 592 439 592 336C592 176 505 36 319 36C246 36 213 55 213 131V547Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,16.642,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g><g transform="matrix(.013,0,0,-0.013,24.069,0)"><path d="M162 -163V703H101V-163H162Z"></path></g></svg> is the linkage disequilibrium coefficient.</div>

International Journal of Genomics

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Figure 1

Figure 1: Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease 