Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients

<div>The characteristics of the cfDNA in patients with schizophrenia vary significantly as compared with the control. (a) Dependence of the relative cf-rDNA CN, cf-rDNA concentration, and NA values on the relative cfDNA concentration for the control and SZ groups. The relative values are obtained by means of dividing the respective value by the maximum value in each index group. The legend of the parameters is given in (a) in the box. The vertical and horizontal lines separate the values of relative cfDNA and NA parameters for the control group. (b) Comparison of cfDNA and cf-rDNA concentrations and index NA and cf-rDNA CN in SZ subgroups I-IV and the control group. <svg height="8.8423pt" id="M77" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 9.58606 8.8423" width="9.58606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M715 650H476L470 622C550 619 562 610 562 570C562 536 553 481 535 384L523 321C485 121 408 37 283 37C178 37 99 109 134 297L178 532C193 612 199 616 278 622L284 650H29L23 622C105 616 109 609 94 532L48 291C23 160 51 83 98 40C143 -1 202 -16 260 -16C321 -16 387 3 439 49C509 111 542 204 563 312L577 384C595 479 608 533 619 569C629 603 637 620 709 622L715 650Z"></path></g></svg> test data are given.</div>

International Journal of Genomics

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Figure 4

Figure 4: Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients 

Figure 4 | Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients 