Research Article

Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma

Figure 5

Protein-protein interaction (PPI) network, hub gene screening, and module analysis. (a) The PPI network constructed using STRING 11.0 was visualized by Cytoscape. The upregulated genes are shown in green, while the downregulated genes are shown in bluish violet. (b) The network directly associated with the top ten hub genes identified by CytoHubba. (c) The network of the top ten hub genes filtered according to the degree method provided by CytoHubba. (d, e) The key modules identified using the MCODE plugin of Cytoscape, which contains 27 nodes/344 edges and 16 nodes/34 edges, respectively.