The Necessity of Prenatal Diagnosis by CMA for the Women with NIPS-Positive Results

Table 1

The comparison between NIPS, CMA, and conventional karyotyping.

	NIPS	Karyotype analysis	CMA
Technology positioning	Prenatal screening	Prenatal diagnosis	Prenatal diagnosis
Cell culture	N	Y	N
Cost	Middle	Low	High
Reporting time	1~2 weeks	4~5 weeks	1~2 weeks
Aneuploid	Y (mainly to T21/T18/T13)	Y	Y
Large fragment (>10 M)	Sometime	Y	Y
Microdeletion/microduplication (<10 M)	Sometime	N	Y
Balanced translocation	N	Y	N
Unbalanced translocation	N	Y	Y
Loss of heterozygosity (LOH)	N	N	Y
Uniparental disomy (UPD)	N	N	Y

This table only compared the application of these three techniques in prenatal screening and diagnosis.