Research Article
Reevaluating the Mutation Classification in Genetic Studies of Bradycardia Using ACMG/AMP Variant Classification Framework
Table 2
Sequence variant classification.
| Pathogenic | | | | | ≥2 (PS1-PS4) | | | |
| Likely pathogenic | | | | ≥3 (PP1‐PP5) | | |
| Benign | 1 BA1 | ≥2 (BS1–BS4) |
| Likely benign | | ≥2 (BP1‐BP7) |
| Uncertain significant | Other criteria shown above have not met OR | Criterion for benign and pathogenic is contradictory |
|
|
OR: odds ratio.
|