Reevaluating the Mutation Classification in Genetic Studies of Bradycardia Using ACMG/AMP Variant Classification Framework

Table 2

Sequence variant classification.

Pathogenic
	≥2 (PS1-PS4)
	Likely pathogenic
		≥3 (PP1‐PP5)
		Benign	1 BA1
			≥2 (BS1–BS4)
		Likely benign
			≥2 (BP1‐BP7)
Uncertain significant	Other criteria shown above have not met OR
	Criterion for benign and pathogenic is contradictory

OR: odds ratio.