Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas

Figure 4

TLX1NB distribution in different subsets. (a) TLX1NB distribution between grade II and III LGG. A value < 0.05 was selected as the significance threshold. (b) High expression of TLX1NB in the NB group compared with PG and EPL. A value < 0.05 was selected as the significance threshold. NB: neuroblastic; PG: preglioblastoma; EPL: early progenitor-like. (c) Low expression of TLX1NB in the PTEN deletion group. A value < 0.05 was selected as the significance threshold. (d) No difference for TLX1NB between PTEN methylation and unmethylation group. A value < 0.05 was selected as the significance threshold. (e) High expression of TLX1NB in the IDH1 mutation group in the TCGA dataset. A value < 0.05 was selected as the significance threshold. (f) No difference for TLX1NB between IDH1 mutation and wildtype group in GSE35158. A value < 0.05 was selected as the significance threshold.

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