|
Gene | SNP | Risk/protective allele | Outcome | Frequency | Population | Reference |
|
Mechanisms of entry of the virus into the cell |
ACE1 | Insertion/deletion (I/D) | D | Higher frequency of hypoxemia | 0.33 | Vietnamese | [18] |
CD209 | -336A>G | G | Lower blood levels of lactate-dehydrogenase (an independent prognostic indicator for severity of SARS-CoV infection) | 0.10 | Chinese | [47, 48] |
CLEC4M | Tandem repeat domain in exon 4 | Homozygotes | Lower susceptibility to SARS-CoV infection incidence | 0.46 | Chinese | [17] |
Immune response/inflammation phenomena |
ICAM-3 | Asp143Gly | Gly | Higher lactate dehydrogenase levels and lower white blood cell counts | 0.10-0.17 | Chinese | [49, 50] |
IFN-γ | +874 A/T | A | Higher susceptibility to SARS-CoV infection incidence | 0.83 | Chinese | [19, 20] |
RANTES | -28C/G | G | Higher susceptibility to SARS-CoV infection incidence and increased risk of death | 0.21 | Chinese | [20, 51] |
OAS-1 | A/G SNP in exon 3 | G | Higher susceptibility to SARS-CoV infection incidence | 0.48 | Vietnamese | [22] |
OAS-1 | A/G SNP at the 3’UTR 347 locus of the exon 8 | G | Lower susceptibility to SARS-CoV infection incidence | 0.24 | Chinese | [52] |
MxA | -123C>A | A | Lower susceptibility to SARS-CoV infection incidence | 0.11 | Chinese | [21] |
MxA | G/T SNP at position −88 in the promoter region | G | Higher frequency of hypoxemia | 0.76-0.82 | Chinese, Vietnamese | [21, 22] |
MxA | G/T SNP at position −88 in the promoter region | GT genotype | Higher susceptibility to SARS-CoV infection incidence | 0.73-0.81 | Chinese | [52, 53] |
IL-12 RB1 | +1664 C/T | T | Higher susceptibility to SARS-CoV infection incidence | 0.29 | Chinese | [54] |
FcgRIIa | H131R | R | Associated with a severe course of the disease (requiring treatment in an intensive care unit) | 0.34 | Chinese | [55] |
MLB | Codon 54 variant (A/B) | B | Higher susceptibility to SARS-CoV infection incidence | 0.34-0.35 | Chinese | [56, 57] |
CCL2 | G-2518A | G | Higher susceptibility to SARS-CoV infection incidence | 0.80 | Chinese | [57] |
AHSG | −799A/T | T | Higher susceptibility to SARS-CoV infection incidence | 0.21 | Chinese | [58] |
TNF-α | -204 | CT genotype | Lower susceptibility to SARS-CoV infection incidence and increased risk of femoral head necrosis | 0.05 | Chinese | [23] |
TNF-α | -308G/A | A | Increased risk of femoral head necrosis | 0.06 | Chinese | [23] |
CD14 | -159C/T | C | Associated with a severe course of the disease (requiring treatment in an intensive care unit) | 0.31 | Chinese | [24] |
HLA-B | B0703 | B0703 | Higher susceptibility to SARS-CoV infection incidence | 0.11 | Chinese | [25] |
HLA-DRB1 | DRB10301 | DRB10301 | Lower susceptibility to SARS-CoV infection incidence | 0.01 | Chinese | [25] |
HLA-B | B4601 | B4601 | Associated with severe cases of SARS-CoV infection (deceased or intubated patients) | 0.60 | Taiwanese | [26] |
HLA-DRB4 | DRB401010101 | DRB401010101 | Higher susceptibility to SARS-CoV infection incidence | 0.51 | Chinese | [59] |
HLA-B | B1502 | B1502 | Lower susceptibility to SARS-CoV infection incidence | 0.26 | Chinese | [59] |
HLA-DRB3 | DRB3030101 | DRB3030101 | Lower susceptibility to SARS-CoV infection incidence | 0.28 | Chinese | [59] |
HLA-DRB1 | DRB11202 | DRB11202 | Higher susceptibility to SARS-CoV infection incidence | 0.47 | Vietnamese | [60] |
HLA-Cw | Cw0801 | Cw0801 | Higher susceptibility to SARS-CoV infection incidence | 0.23 | Taiwanese | [27] |
HLA-Cw | Cw1502 | Cw1502 | Lower susceptibility to SARS-CoV infection incidence | 0.10 | Taiwanese | [28] |
HLA-DR | DR0301 | DR0301 | Lower susceptibility to SARS-CoV infection incidence | 0.11 | Taiwanese | [28] |
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