Construction and Validation of Predictive Model to Identify Critical Genes Associated with Advanced Kidney Disease

Figure 4

WGCNA of ESRD-related genes. (a). Hierarchical clustering dendrogram of genes. Cluster dendrogram was constructed according to gene expressed values in each sample; (b) Hierarchical clustering heat map. Gene clusters in different colors represent for correlation-ship of genes expressed values. A deep color indicated a higher correlation-ship among two genes. (c) Gene coexpression network and modules related to ESRD. In the WGCNA network, the edge weight of 0.05 is considered as a threshold value for screening modules, and points with different colors represented that the genes belong to different modules. (d) The correlation of module-membership and gene significance. The -axis represents the module-membership of genes in ME1 (the values range from 0 to 1). The -axis represents the gene significance for disease (the values range from 0 to 1). Regression analysis was performed on scatter plots to calculate the Pearson correlation coefficient and corresponding value.

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