Clinical Evaluation of the Diagnostic Role of MicroRNA-155 in Breast Cancer

Table 9

Biomarker index of miR-155 for identification of breast cancer by the Youden index three-group model.

Parameters	Sensitivity	Specificity	Youden index	95% CI for Youden	Best cutpoints
					Lower	Upper
Grade	99.76%	88.25%	0.3626	0.27-0.455	1.528	2.638
Stage	42.40%	77.19%	0.4520	0.3055-0.5985	1.335	2.064
Tumor size	35.67%	79.03%	0.4269	0.261-0.5928	1.362	2.172
LNM ()	44.94%	75.17%	0.4588	0.3231-0.5945	1.307	1.974
HER2	38.82%	79.93%	0.3444	0.1939-0.4949	1.376	1.985
PR	35.46%	77.33%	0.4246	0.2921-0.5572	1.337	2.038
ER	80.75%	80.64%	0.3397	0.2332-0.4462	1.387	1.484
Ki-67	28.37%	79.8%	0.3467	0.2156-0.4778	1.363	2.070