Identification of Circulating Exosomal miR-101 and miR-125b Panel Act as a Potential Biomarker for Hepatocellular Carcinoma

Table 2

miR-125b pathway.

KEGG	kegg_dscp	Gene	value	Possibility
ko00514	Other types of O-glycan biosynthesis	B4GALT1, B3GALTL, B4GALT3, FUT7, OGT		0.011742378
ko05219	Bladder cancer	ERBB2, CDKN2A, TP53, E2F2, NRAS, RAF1, KRAS		0.017759706
ko05218	Melanoma	CDKN2A, TP53, E2F2, NRAS, CDK6, FGFR1, RAF1, KRAS		0.017526623
ko05217	Basal cell carcinoma	CTNNB1, TCF7, FZD4, AXIN2, AXIN1, SMO, PTCH2, TP53		0.015535401
ko05216	Thyroid cancer	TCF7, TP53, NRAS, RET, CTNNB1, TPR, KRAS		0.026347694
ko05215	Prostate cancer	ERBB2, TCF7, TP53, E2F2, CDKN1B, NRAS, CREB1, CTNNB1, FGFR2, IKBKG, BCL2, KRAS, RAF1, FGFR1		0.017111648
ko05214	Glioma	CDKN2A, TP53, E2F2, NRAS, CDK6, RAF1, KRAS		0.011336943
ko05213	Endometrial cancer	ERBB2, TCF7, TP53, AXIN2, AXIN1, NRAS, CTNNB1, ELK1, RAF1, KRAS		0.028333084
ko05212	Pancreatic cancer	ERBB2, CDKN2A, STAT3, RAC3, SMAD4, E2F2, ARHGEF6, IKBKG, CDK6, TP53, RAF1, KRAS		0.021190757
ko05210	Colorectal cancer	TCF7, TP53, RAC3, AXIN1, SMAD4, JUN, CTNNB1, BCL2, KRAS, RAF1, AXIN2		0.020677737
ko00603	Glycosphingolipid biosynthesis-globo series	A4GALT, GBGT1, NAGA		0.017862543
ko00601	Glycosphingolipid biosynthesis-lacto and neolacto series	B3GNT5, GCNT2, FUT7, FUT3, B4GALT1, B4GALT3		0.023770631
ko05332	Graft-versus-host disease	IFNG, IL6, CD28, PRF1		0.019578864
ko04722	Neurotrophin signaling pathway	TP53, NRAS, MAP3K1, JUN, KIDINS220, TP73, NTRK3, PRDM4, ABL1, MAP2K7, BCL2, IRAK3, SORT1, CRK, IRAK1, RAF1, MAPKAPK2, KRAS		0.018112601
ko04012	ErbB signaling pathway	ERBB2, ERBB3, EIF4EBP1, JUN, NRAS, PAK3, ELK1, MAP2K7, ABL1, CRK, ABL2, RAF1, KRAS		0.018457916
ko04370	VEGF signaling pathway	RAC3, NRAS, PXN, RAF1, MAPKAPK2, KRAS		0.011490893
ko04115	p53 signaling pathway	CDKN2A, PMAIP1, PPM1D, TP73, IGFBP3, PERP, CDK6, TP53, BBC3, SERPINE1		0.011151405
ko03013	RNA transport	NUP133, EIF2B5, EIF5, EIF5B, EIF2S3, XPO1, RBM8A, NDC1, EIF4EBP1, NUP210, RANBP2, KPNB1, RNPS1, ACIN1, NUP93, CASC3, TPR, EIF4E, UBE2I, RPP14, NUP37, POP7, NUP155, NUP205		0.013146709
ko05223	Non-small-cell lung cancer	ERBB2, CDKN2A, TP53, E2F2, NRAS, RASSF5, CDK6, RAF1, KRAS		0.019436868
ko05220	Chronic myeloid leukemia	CDKN2A, TP53, E2F2, SMAD4, CDKN1B, NRAS, IKBKG, CDK6, ABL1, CRK, RAF1, KRAS		0.021190757
ko05221	Acute myeloid leukemia	TCF7, STAT3, NRAS, CEBPA, EIF4EBP1, IKBKG, RAF1, KRAS		0.011822332
ko04520	Adherens junction	ERBB2, TCF7, RAC3, WASF2, SMAD4, VCL, CTNNB1, INSR, PTPN1, FGFR1		0.010727212
ko05161	Hepatitis B	IL6, DDX3X, STAT2, STAT3, SMAD4, CDKN1B, MAP3K1, JUN, CREB1, E2F2, ELK1, IKBKG, CDK6, BCL2, TP53, MAVS, RAF1, NRAS, KRAS		0.01254609
ko05162	Measles	MAVS, CD28, STAT3, STAT2, IFNG, CDKN1B, ADAR, IL13, TNFAIP3, IL6, DOK1, TP73, CDK6, TP53, BBC3, IRAK1, TACR1		0.010775044

The detailed miR-125b pathway was associated with different cancers and signaling pathways and their targeted genes based on the TCGA database.