Research Article
Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma
Figure 5
Consensus clustering analysis shows two clusters of ccRCC patients with differential prognosis. (a) Cumulative distribution function (CDF) curves for the consensus score ( to 9). (b) The tracking plot for to 9. (c) Consensus clustering matrix for the optimal cluster number, . (d) Principal component analysis of the total RNA expression profile. ccRCC in cluster 1 and 2 are marked in red and blue, respectively. (e) Kaplan-Meier overall survival (OS) curve for ccRCC patients in cluster 1 and 2. (f) The expression heatmap of the 12 m5C methylation regulatory genes in cluster 1 and cluster 2 patients that were stratified according to the clinicopathological parameters: namely, N stage (N0, N1, or NX), M stage (M0, M1, or MX), T stage (T1-T4), AJCC stages (stages I, II, III ,or IV), grade (G1-G4), gender (male or female), age (>65 y or <65 y), and survival status (alive or dead). , , and .
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