Comprehensive Analysis of m⁵C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma

Figure 6

Construction and evaluation of the m⁵C RNA methylation-related prognostic risk signature in the training cohort. (a) Univariate Cox regression analysis results show the values and hazard ratios (HR) with confidence intervals (CI) of the twelve m⁵C RNA methylation regulatory genes. (b) The Venn diagram between differentially expressed genes and genes related to OS. (c, d) The 7 prognostic risk signature genes were selected by LASSO Cox regression analysis. (e) Kaplan-Meier survival curves show the overall survival (OS) rates of high-risk () and low-risk () ccRCC patients of the training cohort. The high-risk group shows shorter OS compared to the low-risk group. (f) The accuracy and reliability of the prognostic risk signature in determining the 1-year, 2-year, and 3-year survival outcomes of the high- and low-risk patients in the training cohort. (g) The expression heatmap of the seven prognostic risk-related m⁵C RNA methylation regulators in the high-risk (blue) and low-risk (pink) ccRCC patients of the training cohort. ; . (h) The distributions of risk scores of the high-risk (red) and low-risk (blue) ccRCC patients and corresponding survival time (the red dots represent the dead patients and the blue dots represent the alive patients) in the training cohort.

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