Quantile-Dependent Expressivity of Serum Uric Acid Concentrations

Figure 1

(a) Offspring-parent regression slopes () for selected quantiles of the offspring’s uric concentrations from 12,068 offspring-parent pairs, with corresponding estimates of heritability ( [32], where the correlation between spouses was . The slopes became progressively greater (i.e., steeper) with increasing quantiles of the uric acid distribution. (b) The selected quantile-specific regression slopes were included with those of other quantiles to create the quantile-specific heritability function in the lower panel. Significance of the linear, quadratic, and cubic trends and the 95% confidence intervals (shaded region) determined by 1000 bootstrap samples.

(a)

(b)